The second Madballs series by Art Asylum was released in 2008. Like the new first series, the new second series had six Madballs consisting of five old Madballs and one new Madball.

The old Madballs were:

The new Madball introduced was Blech Beard.

This was the final series produced by Art Asylum, due to a merger between Basic Fun (also behind the new Madballs) and Good Stuff, Inc.